Getting Started with GLP-1 Medications
Everything you need to know about semaglutide and tirzepatide, from how they work to getting your first prescription.
Not medical advice
This content is for informational purposes only and does not constitute medical advice. GLP-1 medications are prescription-only. All use should be supervised by a licensed healthcare provider.
What Are GLP-1 Medications?
GLP-1 receptor agonists are a class of medications that mimic hormones your body naturally produces to regulate blood sugar and appetite. They were originally developed for type 2 diabetes but have gained widespread use for weight management.
There are two main medications in this category:
Semaglutide
A GLP-1 receptor agonist. Sold under the brand names Ozempic (diabetes) and Wegovy (weight management). Works by slowing digestion, reducing appetite, and improving insulin sensitivity.
Tirzepatide
A dual GIP and GLP-1 receptor agonist. Sold under the brand names Mounjaro (diabetes) and Zepbound (weight management). Targets two gut hormones instead of one, which may provide additional metabolic benefits.
Both medications are typically administered as a once-weekly subcutaneous injection, though some compounded versions are available as oral tablets, drops, or sublingual formulations.
What to Expect
Most people notice reduced appetite and fewer cravings within the first few weeks. Many describe a quieting of "food noise," where the constant mental chatter about food fades. Weight loss typically follows as your caloric intake naturally decreases.
Common benefits
- + Significant appetite suppression and reduced cravings
- + Steady, sustained weight loss over weeks and months
- + Improved insulin sensitivity and lower fasting glucose
- + Reduced food noise and emotional eating
Common side effects (often temporary)
- ! Nausea, especially when starting or increasing dose
- ! Constipation or diarrhea
- ! Bloating, gas, or acid reflux
- ! Fatigue, headache, or mild dizziness
- ! Injection site irritation
Side effects often subside after a few weeks as your body adjusts. Not everyone experiences them. Starting at a low dose and titrating slowly helps minimize discomfort.
When to contact your doctor
- Persistent vomiting where you cannot keep fluids down
- Severe stomach pain radiating to your back (possible pancreatitis)
- Yellowing of the skin or eyes
- Severe constipation or abdominal pain that does not resolve
How to Get a Prescription
GLP-1 medications require a prescription from a licensed healthcare provider. The most common route is through a telehealth provider that specializes in weight management. The process is straightforward:
Complete a health questionnaire
Most providers start with an online intake form covering your medical history, current medications, and weight loss goals.
Lab work (if required)
Some providers require basic labs like a comprehensive metabolic panel (CMP) or A1C test. Others include lab work in their service.
Provider review or telehealth visit
A licensed provider reviews your information and determines if GLP-1 medication is appropriate for you. Some require a video visit, others review asynchronously.
Pharmacy fulfillment
Your medication is prepared by a partner pharmacy and shipped directly to you, typically within a few days.
Not all providers operate in every state. Always verify state availability before signing up.
Brand-Name vs. Compounded
Brand-name GLP-1 medications (Ozempic, Wegovy, Mounjaro, Zepbound) are manufactured by large pharmaceutical companies and can cost $1,000 or more per month without insurance. Compounded versions contain the same active ingredient but are prepared by licensed compounding pharmacies, often at significantly lower prices.
503A Pharmacies
Smaller compounding pharmacies that prepare medications for individual prescriptions. They compound based on a specific patient's prescription from a licensed provider.
503B Outsourcing Facilities
Larger facilities registered with the FDA that can produce compounded medications in larger batches without individual prescriptions. They follow stricter manufacturing and quality standards.
The providers listed on GLP321.com primarily offer compounded versions through licensed telehealth platforms. Our comparison tool helps you evaluate these providers based on price per milligram so you can make informed decisions.
Dosing and Titration
Both medications follow a gradual titration schedule, starting at a low dose and increasing over time. This approach minimizes side effects and lets your body adjust. Always follow your provider's specific instructions.
Tirzepatide titration
Semaglutide titration
Some people remain at lower doses long-term if they are responding well. Titrating slowly is one of the best ways to reduce side effects. Never increase your dose faster than your provider recommends.
Dosage Conversion Guide (Tirzepatide)
Compounded tirzepatide comes in different concentrations. Use this chart to determine how many units to draw based on your prescribed dose and your vial's concentration. Always confirm with your pharmacy or provider.
| Dose | 5 mg/mL | 10 mg/mL | 15 mg/mL |
|---|---|---|---|
| 2.5 mg | 50 units | 25 units | 17 units |
| 5 mg | 100 units | 50 units | 33 units |
| 7.5 mg | - | 75 units | 50 units |
| 10 mg | - | 100 units | 67 units |
| 12.5 mg | - | - | 83 units |
| 15 mg | - | - | 100 units |
U-100 insulin syringes have 100 units per 1 mL. For a 10 mg/mL vial, each unit equals 0.1 mg of tirzepatide. Compounding concentrations can vary between pharmacies, so always verify your specific vial's label.
Injection Basics
Compounded tirzepatide and semaglutide typically come in vials measured in mg/mL. You draw and inject the medication yourself using insulin syringes. It sounds intimidating at first, but most people get comfortable within a few doses.
Where to inject
Subcutaneous injection into the abdomen, thigh, or back of the upper arm. Rotate sites each week to avoid irritation.
When to inject
Once per week on the same day. Pick a consistent day and time that works for your schedule.
Supplies you will need
- U-100 insulin syringes (if using vials)
- Alcohol swabs for cleaning the injection site
- Sharps container for used needles
Storage
Store medication in the refrigerator unless your pharmacy directs otherwise. Do not freeze.
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Disclaimer
The information on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. GLP-1 medications are prescription-only and should only be used under the supervision of a licensed healthcare provider. Always consult your physician before starting, stopping, or changing any medication. Dosing schedules and conversion charts are provided as general reference and may not match your specific prescription. Verify all dosing with your prescribing provider and pharmacy.